vshost-clr2.exe has stopped working

I'm working on an app in VS 2010 on wind2008. It's a .Net 3.5 app that use .Net 2.0 library.

I change all Frameworks to 3.5 .Net and uncheck "Enable the visual studio hosting process"

But When I debug my solution I got this error :

Problem signature:
  Problem Event Name:   APPCRASH
  Application Name: AnalyseFarm.exe
  Application Version:  1.0.0.0
  Application Timestamp:    5326f157
  Fault Module Name:    KERNELBASE.dll
  Fault Module Version: 6.1.7600.16385
  Fault Module Timestamp:   4a5bdfe0
  Exception Code:   c000041d
  Exception Offset: 000000000000aa7d
  OS Version:   6.1.7600.2.0.0.274.10
  Locale ID:    1036
  Additional Information 1: 5ecb
  Additional Information 2: 5ecbd308407466ba89616cb69c9e62d8
  Additional Information 3: 9ac0
  Additional Information 4: 9ac06af1219db569f0ee193c24745b31

any idea , beast regards