Does .Net 3.5 or .Net 4.0 support Format16bppGrayScale TIFFS

I've read a lot of articles that say that Format16bppGrayScale is not supported in .NET 2.0 (and confirmed this), however there are "suggestions" that it will work in .Net 3.5 +

I have a byte[] array that I want to save in 16bit Tiff format. 

I've tried the SetPixel and LockBits examples out there (in .Net4.0) and still get the same errors as in .Net 2.0.